This week, we dive into the heart of UVA’s chemistry department with Jill Venton, its chair and the Thomas Jefferson Professor of Chemistry. She tells us about the fascinating study and synthesis of the molecular building blocks of our universe: from star formation to nanoparticles for clean energy applications, and borrowing fluorescent molecules from fireflies to illuminate our own biological processes. We also discuss her lab’s research on brain chemistry and the future of neurochemical treatments for disease.
- Transcript
welcome to Who's in STEM I'm Ken Ono your host and the STEM adviser to the Provost and the Marvin Rosen Blum
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Professor of Mathematics at UVA Our goal is to evoke flights of imagination and
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wonder by showcasing the cornucopia of all that is STEM at UVA the marvelous
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world of UVA science technology engineering and
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mathematics The other day I made a list of the exciting and significant UVA STEM
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discoveries inventions and projects that we've covered on this podcast And if you
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list them alphabetically like I did the A's alone are quite amazing Do you get that a's alone are amazing A bunch of
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A's But more seriously we've talked about AI artificial intelligence We've
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talked about the artificial pancreas that A We've talked about autonomous vehicles And for another A we've talked
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about the very serious crippling disease Alzheimer's Going beyond the A's the
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list goes on and includes lots of exciting things the new Manning Biotechnology Institute the brain
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institute data science the environmental institute the link lab Last week we talked about national security and so
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on STEM is really happening and happening big at the University of
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Virginia It's clear that we're much more than Thomas Jefferson's university the
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university of secret societies and the university with the rotunda Now in who's
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in STEM we also feature and talk about the basic sciences And as a mathematician I have to assure you that
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the basic sciences come before everything else that I've just described above We've had episodes on astronomy
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biology mathematics physics and statistics The basic sciences they're
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fundamental and essential to our foundational understanding of nature and just basically how the world works And
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along these lines today it's my great pleasure to talk about chemistry When I
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was 10 my parents got me a kids chemistry set that came in a large box with a handle Although I don't ever
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remember taking it anywhere You could see the little bottles of chemicals and glassear through the clear plastic It
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was so cool Ever the science nerd i'd go to my basement put on the goggles and
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perform experiments with my dog Eigor by my side What kind of experiments well
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the grosser the better Here are some of my favorites The stink bomb based on the
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production of hydrogen sulfide from odorless sulfur the volcanic lava flow
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made by combining baking soda with vinegar And well I also love the
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invisible ink This was a simple experiment just made with a lemon juice concoction You see messages emerged when
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the lemon juice ink was exposed to heat teaching us about the power of oxidation
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The oxidation and the heat turns the ink brown I also love the mesmerizing
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underwater fireworks that formed in a clear glass beaker all due to gravity
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What did that experiment teach us it was nothing more than well a few eyroppers and a bunch of different colored fluids
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that came with different densities Now make no mistake the stuff of modern-day
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chemistry is nothing like the stuff of my basement experiments And chemistry is
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thriving at the University of Virginia And we want to talk about it today And it's a pleasure to be joined by Jill
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Venton the Thomas Jefferson Professor of Chemistry and the current chair of UVA's
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chemistry department Jill welcome to Who's in STEM Thanks Ken It's great to be here So Jill so much to talk about
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Chemicals are everywhere around us Chemistry is obviously much more than my juvenile fascination with stink bombs
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and invisible ink Now as a college student I took some chemistry classes
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They weren't my best classes The courses that I remember taking went by the names
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like OEM PCM Chem 101 That was the very first one And generally these classes were offered at 8:00 Here at UVA as
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department chair what's chemistry thanks Ken So chemistry is really the study of
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molecules that make up all of matter from air to space to the human body And
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so chemists really study those tiny building blocks of life And so much of the matter of living things is made up
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of molecules that have carbon as their center And so chemists call the study of
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anything with carbon organic chemistry We tend to call it organic here instead of Ochem but that's one of the main
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specialties of chemistry Now if you study basically any element on the periodic table besides carbon we call
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that inorganic chemistry Inorganic and organic chemists together often are
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called synthetic chemists That's because they often make new molecules So they're interested in the science of making
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molecules But not all chemists make molecules Some of them just study molecules So there's other areas of
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chemistry that are interested in studying molecules For instance physical chemists or pchemists study the physical
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properties of molecules such as maybe how a molecule interacts with light And
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then many of them use those studies to model and predict different chemical
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properties or behaviors Analytical chemists that's what I am do a lot of analysis of samples to understand what
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chemicals are present in them So examples of analytical chemistry include
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things like forensics to look at drugs in a sample or measuring an
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environmental sample to see what contaminants are in it And then there lastly there's biochemists They combine
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biology and chemistry to understand really the molecules that make up
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everyday living systems things like proteins and DNA Jill thanks for that very quick lesson Now at UVA you chair
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the department of chemistry and you just told about many different disciplines within chemistry Tell us about the
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makeup of the department and how the faculty you have represent these various fields All right So the mission of our
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chemistry department at University of Virginia is to perform cutting edge chemical research while training the
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next generation of chemical scientists And so we're a large department We have about 30 tenure track faculty And so
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these are faculty that both teach and then run research groups And then we also have about six teaching track
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faculty that primarily concentrate on teaching chemistry And so every year we
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have about a hundred students graduate with a bachelor's degree in chemistry
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and another 8 to 10 with a master's degree and then about 15 to 20 that get a PhD or a doctoral degree in chemistry
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Also a fun fact each year we have about 10,000 student enrollments in chemistry
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courses So those are separate Some students take more than one course but that just shows you how large a
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department we are Did you say you have 10,000 chemistry students 10,000 butts
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and seats in your chemistry classes yes that's true We have over 10,000 student
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enrollments or butts and seat in chemistry classes We are a large operation because chemistry really
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touches so many other disciplines So for instance many science and engineering
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majors will require a chemistry course in theirs And of course we all know that
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many of the premed students as well enjoy taking a lot of our uh chemistry classes Uh and so we're able to do a lot
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of uh good teaching but also research Our department brings in approximately 12 to 14 million a year in external
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funding uh for chemistry research and both undergraduate and graduate students
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participate in that research mission So Joe that's that's amazing I remember when I was taking chemistry in college I
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thought of every professor as the leader of kind of a significant enterprise Are you saying that we have 30 chemistry
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tenure track and tenure faculty members does that mean we have roughly 30 different research labs here at UVA yes
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that's what that means And each lab works on a slightly different topic but
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it's really fascinating to think that we have so many different labs and so many experiences that our students can have
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to really learn about chemical research Well that's really quite an operation Now among these 30 professors and I'm
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sure they're all doing fascinating things and our time is limited but I do think it's important if you could share
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with us some examples can you show and tell us about some of the exciting
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research that's going on in your department uva chemistry has many unique specialties that I'd like to highlight
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So one of these specialties is astrochemistry which is studying the chemistry of space and how stars form So
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tell us about that I would have thought that space largely is a vacuum So that we have faculty studying astrochemistry
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is fascinating Must be a fairly new field I didn't learn about it certainly in high school Tell us about it Yeah So
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astrochemistry takes advantage of some of the latest and greatest telescopes that have been designed to really
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measure spectroscopic or how molecules interact with light signals in the far
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away space And so people like Professor Rob Grod and Professor Eric Herpst and
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then Professor Ilsa Cleaves who has a dual appointment between astronomy and chemistry they look at these molecules
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look at the spectra that they get from telescopes and then try to recreate sometimes some of those reactions in a
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chemistry lab to understand how molecules are formed in space So another
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specialty uh that's really been growing at uh University of Virginia is inorganic chemistry and
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catalysis So clean energy applications such as solar energy require a catalyst
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And so that catalyst's job is to be a helper to turn something like sunlight
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into a molecule that we can use for energy And so our department has a lot
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of expertise now in developing new catalysts and nano particles to be able to transform energy applications In fact
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last year we even had the secretary of energy Jennifer Granholm come and visit
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our department because of the well- reggarded programs we have and the fact
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that we have been awarded several Department of Energy Center grants to
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study catalysis Well that's really interesting So I think all of us understand the need for clean sources of
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energy That's that's this is that's a given The process to me sounds a little bit like the process that one goes
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through when trying to find new drugs right in your search for new catalysts
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you need to find the chemicals or the molecules or the compounds that work are
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inexpensive cost effective do not do damage when implemented so on and so
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forth So I'm excited to see that we've got multiple labs presumably working on all of these different questions Yeah So
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the problems that you listed Ken are absolutely correct A lot of our focus
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now is on making catalysts from more earthabundant metals Not rare metals
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that are hard to find and very expensive but instead iron or things like that
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that are very abundant and trying to make better catalysts from that And that's going to be more eco-friendly and
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also more cost productive So a final area we have a lot of expertise in the chemistry department is biomed
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applications of chemistry So we have several groups of those organic chemists
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who make drugs for things like cancer applications So we also have groups that
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develop different molecules that emit light We call that fluorescent And they
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use these fluorescent molecules then to track different proteins or different
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membranes in the body uh and in tissue to really understand the basics of
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biochemistry And we even have some professors here who have done uh
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analytical experiments to develop devices such as professor Landers who developed some COVID testing or
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professor Pompano She was able to develop a device that can keep some thin
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pieces of tissue alive and then really study the molecular interactions that are happening in a piece of tissue Wow
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Among these chemists do some of them have joint appointments with our school of medicine or some of these research
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projects shared projects with our medical professors yes absolutely Many
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of our faculty have a joint or a courtesy appointment in the school of medicine and also our graduate faculty
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in the biomed sciences program One of the things I love about UVA is that the barriers are really low to collaborate
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and having the medical school on grounds in the same location as the chemistry
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department means that it's very easy just to walk down the street and be able to work with different biomedical labs
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So Jill the fluoresence is fascinating I only think of two things really First of all how to spell fluorescent It was a
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spelling word uh in second grade a hard one But I also think about the flickering old fluorescent lights And I
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think about like a fluorescent bay that I recently visited where the organisms
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have this ability to bofllores So tell us tell us about the work and the
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applications of fluoresence So one of the examples of fluoresence that I think about in nature is the
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firefly And so it turns out the firefly has a chemical reaction that happens to
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make it light up And we call that enzyme that does that firefly luciferase Well
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it turns out when I talk about making assays to turn on some fluorescents in
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the body to look at a protein that we often are borrowing from nature And so
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in this case we can borrow the enzyme like firefly luciferase and then use it
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to make a luciferase then reaction that might be able to track a different type
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of enzyme in the body And we talked before a little bit about catalysis and that inorganic people were using
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elements like iron to make catalysts Well it turns out enzymes are the body's catalysts They are biomolecules proteins
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that change one molecule to another And so we borrow from nature like the
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luciferase to understand other types of enzymes in the body That reminds me of
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one of our earlier episodes with former UVA vice president of research Mel Ramos
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Sububbermanian And I asked him uh what he was most well known for in his research And he had a very similar story
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where instead of studying the firefly he studied the mosquito And it was on a
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trip to some faraway camp I believe it was in northern Wisconsin where he got
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bit by a mosquito and he had a flash of insight and he thought that by studying
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the mosquito he could improve uh vaccine needles and that turned out to be one of
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his research accomplishments that he's most well known for So I love it when we learn from nature We want to understand
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nature and of course that requires first trying to study and then in I guess some cases emulate what nature does so well
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Now Jill I know as chair you've described a number of the research projects and the work of the faculty in
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your department That's rather humble I've got to talk about you too Tell us about your research I want to know what
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are you known for obviously it's significant You're the Thomas Jefferson Professor of Chemistry It's an honor
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that recognizes your scholarship Tell us about it So my area of research is
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really neurochemistry So neurochemistry again is the study of chemicals in the brain
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My expertise is designing tiny little electrochemical sensors that allow us to
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peer into the brain and really understand neurochemistry So part of my
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lab develops these tiny little sensors and we use really cool new technology like nano 3D printing And so we can make
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electrodes that are only a few hundred nanometers wide So that's like 1/100th
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the size of a human hair We take these electrodes and we use them to study
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chemical signaling in the brain And we call this chemical signaling neurotransmission So you have neurons in
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your brain and they all communicate by releasing little packets of
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neurotransmitters And that's what my lab wants to measure and understand How does
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your brain communicate using neurotransmitters and so we know that this
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neurotransmission can change often during disease So it's really important to study both the healthy brain to
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understand how it works normally and then we use our techniques to study
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disease models to understand how neurotransmission might change during
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disease My lab for instance studies model organisms and so we've become an
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expert in fruitfly neurochemistry Believe it or not the fruitfly has very similar neurotransmitters to what you
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and I have It's very easy to do genetic models in the fruitfly And so for
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instance our lab has taken a genetic model of Parkinson's disease where we've
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inserted a gene that's known to cause Parkinson's disease and then we've studied how that changes your dopamine
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neurotransmission So we do a lot of studies on dopamine It's a neurotransmitter that's important in
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locomotion and walking and also in addiction and reward So we can take our
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tiny little sensors and insert it into a tiny little fruitfly brain and then understand how dopamine is changing in
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Parkinson's mutations Perhaps not surprisingly what we found in this study
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is that the effect of having the Parkin gene that caused Parkinson's disease is
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worse in older flies than it is in younger flies So again this is a disease
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that often happens in aging And so we see a lot more deficits in dopamine
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neurotransmission in aged flies with Parkinson's disease than in younger
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flies with Parkinson's disease So Joe lots of questions there My first question is rather naive How old is an
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old fruitfly they're not very old which makes it a great project for graduate and undergraduate students It's just
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about 45 days So the lifespan of a fruitfly is only about 60 days So that's
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one of the reasons it's such a great model organism We don't have to wait years for it to get old It's just a
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couple months is the idea then that you can also use the chemical sensors that
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you've produced in other organisms Yeah that's the ideas So right now our
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particular goal is usually to understand neurotransmitters in model systems We're
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not particularly interested in going to humans It would be an invasive technique that might not be well suited But we do
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have some studies for instance in mice as well So another fun study that we're doing right now is to look at the
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effects of focused ultrasound on your brain chemistry So UVA has a lot of
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expertise in focused ultrasound and this is a project that I'm working on with
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Wendy Lynch who is a professor of psychiatry and she and I were able to
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get both three Cavaliers funding and brain institute funding as a seed
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project that led to us getting an NIH grant then to study uh focused
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ultrasound as a possible treatment for addiction So we are currently in rats
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We're studying this in model organisms But what we're doing is we're applying focused ultrasound So this is really
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sound waves that go through your brain So no blood no scalpel No scalpel
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because you can just sit the focus ultrasound on your intact scalp So it's noninvasive You don't have to do real
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brain surgery And so you apply some sound waves and we're applying them at a low frequency So it's not going to cause
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um any damage to your brain Instead what my lab is doing now is seeing how this
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changes the neurochemistry And we've been able to work out parameters that
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will either increase the dopamine in your brain or decrease the dopamine in your brain if you use a completely
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different set of parameters Where are you focusing the ultrasound to generate these effects right now we're doing a circuit So we are focusing the focused
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ultrasound on the prey cortex That's an area that's involved in reward and
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motivation And then we're seeing how it changes dopamine in the nucleus encumbent which is important for
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addiction And so the idea is that we are hoping we can use these parameters which
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our lab has worked out and then my collaborator professor Lynch is going to use these parameters to look and see how
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it changes behavior And so the idea is to look at at relapse So you know people
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have been taking drugs they go off the drugs they experience intense feelings of craving And so our idea is if we can
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modulate the neurochemistry using this non-invasive focus ultrasound we might
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be able then to reduce craving and help people stay off drugs Well Joe that's really great There's so much happening
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there But I also like to talk about the future Time flies and in the world advances an incredible rate certainly in
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the world of AI and a world a wash in data tell us about the future of chemistry research Maybe show and tell
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us about some potential applications that would affect us all Right So I think that chemistry is really at the
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heart of many scientific innovations So like we just talked about my lab is
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trying to understand brain chemistry so that we can eventually regulate it and treat disease and other labs are
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developing novel drugs uh for disease as well And so while we've talked about a lot of fun applications of chemistry I
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want to emphasize that at the heart we are a basic science and a basic research department And so basic science is
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really just understanding the world around us making new molecules
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understanding molecules in nature And you never know where that's going to lead You may invent a synthetic
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technique today publish that in the literature and somebody may pick that up and use that to make an amazing drug in
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the future You may invent an analysis that you use for one thing today but somebody may pick that up and use that
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for the latest COVID testing or whatever the next epidemic or disease of interest is in the future And so I want to
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emphasize that while applications are super cool and important that I think basic science also just doing science to
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study molecules is at the heart of everything we do and that's going to lead I think to some amazing new
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applications and you just never know kind of where the science is going to take you Yeah Thank you Joe It reminds
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me when I was a a a a graduate student many many many years ago One of our
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friends you might know her name was Nancy Gorov and her advisor had just
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invented a molecule I remember her telling me about this and said "How do you invent a molecule haven't these
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things have all happened somewhere in the universe before?" She said "No no." And they call it the Bucky Ball Three
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months later it's the rage I'm learning about it on television It's on the cover of Scientific American and it was an
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example of a carbon compound that mathematically was I guess theoretically
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conceivable Some might be something that a theoretical mathematician might come up with but turned out to be a major
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discovery in the real world And I and I thought that was fascinating So I'm glad that continues to this day So Jill I
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want to talk about your career path It's something that I'd like to talk about with everyone that's on the podcast Can
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you tell us when you when were you first drawn to chemistry was it high school elementary school did you do experiments
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in the basement with your dog like I did yeah So I grew up in the Maryland suburbs of Washington DC And so my dad
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was actually a chemistry professor So apple doesn't fall far from the tree It does not And but he taught at a small
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college called Galedet University which is the university for the deaf And so my
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dad actually taught chemistry in sign language which still blows my mind I'm fluent in ASL but I can't teach
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chemistry uh in ASL And so I was around chemistry uh from my whole life I feel I
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would go and visit my dad's lab sometimes in the summer and I was just kind of interested in chemistry Um and I
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got into a special competitive science and technology school called Elellanena Roosevelt High School in Green Belt
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Maryland And then I was surrounded in high school by all these kids who were just amazing and interested in STEM I
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loved AP chemistry and we were required to do an independent research project at
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this science and technology school And so I ended up working in a lab at the US
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Department of Agriculture at something place called the Beltsville Agricultural Research Center And in this lab it was a
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chemistry lab Uh they made insect attractants And so I wrote a high school
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thesis entitled monofllorinated analoges of methyl eugenol as attractants for the oriental fruitfly You probably have no
26:24
idea what that means but I think it shows I was doing a high level of science uh in high school right and so I
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knew I wanted to study chemistry in college I went on to the University of Delaware They had an amazing honors
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program that allowed a lot of research experience So I was able to study chemistry there um and do some research
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I began studying analytical chemistry there studying mass spectrometry of DNA
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and I also was able to do a research exchange program where I went over to London and went to Imperial College and
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there I started to study bio sensors which is pretty much what I still study uh today And so those experiences really
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shaped me gave me great research experience early I went on to study um
27:08
at the University of North Carolina at Chapel Hill for graduate work and my adviser there really was in the heart of
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this field of doing analytical chemistry and neuroscience and so I got into that
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field and I just absolutely fell in love you know did a posttock with a psychologist doing behavior and
27:27
neurochemistry at the University of Michigan and then I came here to University of Virginia in 2005 and have
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worked my way up all the way from assistant professor to associate to professor to chair Uh I love it here and
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I've really uh had a great time establishing my career here That's super exciting The apple doesn't fall far from
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the tree I I get that My my father was a mathematician and when I was a kid different from your experience in the
27:51
lab but as a kid my dad would sit me at a little table and I'd have to do geometry problems in the summer while he
27:58
did his big boy research I actually didn't think that was very cool So as department chair I feel the need
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to talk about the undergraduate program So as I understand it UVA chemistry has
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done a deep dive thought very seriously about redesigning or updating the
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undergraduate curriculum Tell us about that Yes So we've spent a lot of time really thinking about the success of all
28:23
of our students in chemistry classes at the University of Virginia And the chemistry faculty really have a heart
28:29
for this And so what we realized was that in some of our chemistry classes
28:34
underserved students and first generation students didn't always do as well as more traditional background
28:41
students And so we had a team of faculty including uh Professor Linda Columbus Kevin Welch Lisa Morochuk Marilyn Stains
28:49
and they worked with also some staff members at the College of Arts and Science to redesign our general
28:54
chemistry curriculum And so what we have now is just one lecture per week where we introduce material and then one
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team-based active learning class per week where you work with a group of students to work through problems and
29:09
get a deeper understanding of the material And so this radical change has
29:14
really improved student performance for all groups of students but especially underserved students who now have a team
29:20
to help them understand concepts And so we've now really expanded this active learning to many of our different
29:26
classes in the undergraduate curriculum So previously if chemistry was taught
29:32
here in a way that was similar to how I learned chemistry in college in the 1980s it was boring
29:39
lectures 150 of us in a room old professor actually smoking a pipe back
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then Monday Wednesdays and Fridays 8 to 8:50 and frightening exams a couple
29:50
times a semester I want to take a chemistry class It sounds like much more meaningful And right the students are
29:57
really now getting more engaged in their own learning And that's what's so exciting They're not just watching the
30:03
professor do chemistry They're able to do it themselves And in that line we've also redesigned some of our lab classes
30:10
You know a traditional chemistry lab is like a cookbook Mix this mix that get
30:16
this result kind of thing And don't burn down the lab And don't burn down the lab but it doesn't teach you that much It
30:22
doesn't allow you to really learn the scientific method of designing your own experiments We've introduced more active
30:29
learning experiments into the lab as well allowing students the chance to design their own experiments So I'll
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give you an example from the class that I teach I teach the analytical chemistry lab And if you walk in it kind of looks
30:42
like the labs that you see on those TV shows like CSI or NCIS All those amazing
30:49
instruments that just spit out answers on TV they're not quite like that in real life And so my students learn to
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use all of those instruments and analyze real life samples And so at the end of
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the class I give them real life samples like food or vitamins alcohol vanilla
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that kind of thing And I say "Pick an instrument and go back and analyze it like you're the FDA Tell me what's in
31:14
the sample Tell me if it's pure tell me about any contaminants that you see And
31:20
so they're learning real life applications I don't tell them a procedure They have to figure it out themselves And so with that I think
31:27
we're producing much better scientists and much better chemists by allowing them to practice the scientific method
31:34
in these lab courses That sounds fun For students and the members of the UVA
31:39
community that are interested in chemistry they're not already yet in the department How can they learn more about the department and get involved going
31:46
beyond signing up for classes right So I think you could go to our department website to learn about our special
31:52
events and seminars and also we have some social media like LinkedIn that you
31:58
can look at But even more than that if you're out in the community you might actually be able to interact with our
32:04
chemistry graduate student outreach group that's called Chemistry Lead And their mission is to bring chemistry to
32:11
kids And so they're out in the local schools oftentimes local community fairs
32:16
the discovery museum designing simple experiments to allow kids to get excited about chemistry So there you have it
32:23
This has been wonderful Jill let's wrap up with maybe a fun unrelated story maybe a fun tidbit What would you like
32:30
to tell us well if I think about what I love here about Charlottesville I have this real passion kind of for the
32:35
outdoors and we're blessed to live on a large property out in Ivy on the Mechums River And what's so cool about it is
32:42
that there's so much wildlife So just a few weeks ago I was home with my daughter She was sick from school and
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she's like "Mommy look there's a bear on the porch." And they're rambling across the porch is a bear who takes its time
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to enjoy our property with us We're watching him out the window Uh you never know what you're going to see out there
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And so when I'm not too busy doing tons of chemistry experiments in the lab or running my kids around to their sports
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and activities I love to spend time outside And Charlottesville is just such a great place to live and be Well Jill
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thank you very much We're delighted to have you here at UVA leading the chemistry department You're definitely
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fulfilling Jim Ryan's mission for UVA his charge to be great and good in
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everything that we do And I'm Kenono STEM adviser to the provost and the Marvin Rosenlum Professor of Mathematics
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And you've been listening to Who's in STEM Who's in STEM is a production of WTJU
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91.1 FM and the office of the provost at the University of Virginia Who's in STEM is produced by Katherine Kosaboom Claire
33:42
Kerzen Benjamin Larson Mary Garner McGee Katie Nichols and Ria Verma Our music is
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composed and performed by Robert Schneider and John Ferguson of Apples and Stereo Follow us on Facebook
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podcast We'll be back soon with another conversation about scientific and technological innovation at the
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university